Article Text

Clinical studies on tremorgenic mycotoxicoses in sheep
  1. RH Penny,
  2. BM O'Sullivan,
  3. PG Mantle and
  4. BI Shaw


The clinical responses of sheep dosed orally over seven to 14 weeks with the dried mycelium of a soil-borne mould containing the tremorgenic mycotoxin penitrem A are described. An initial tremoring response was gradually overshadowed by an incoordination syndrome similar to that seen in ryegrass staggers. In spite of protracted staggers symptomatology, correlated with in vitro changes in the release of neurotransmitter amino acids from corpus striatum nerve ending preparations, no histopathology was evident in the wide range of neural and other tissue studied. The biochemical nature of this reversible mycotoxicosis is discussed.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.