TABLE 2:

Bacteriological cure rate by treatment strategy, time of examination and evaluation criteria by EMEA and DVG

Day of examination and bacteriological status at day 0Treatment strategy
Individualised homeopathy (n = 60)Placebo (n = 60)Antibiotic (n = 60)
EMEA*DVG *EMEADVGEMEADVG
n/n%n/n%n/n%n/n%n/n%n/n%
Day 7
 Positive (n=120)
  BacC17/4042.510/4025.017/3844.712/3831.634/4281.030/4271.4
  NoBacC8/4020.08/4020.04/3810.54/3810.55/4211.95/4211.9
  NewInf7/4017.55/3813.24/429.5
  Non-responders15/4037.515/4037.517/3844.717/3844.73/427.13/427.1
 Negative (n=60)
  BacC19/2095.012/2060.022/22100.017/2277.318/18100.013/1872.2
  NewInf7/2035.05/2222.75/1827.8
  Non-responders1/205.01/205.00/220.00/220.00/180.00/180.0
Day 14
 Positive (n=120)
  BacC14/4035.012/4030.018/3847.413/3834.228/4266.723/4254.8
  NoBacC5/4012.55/4012.50/380.00/380.04/429.44/429.4
  NewInf2/405.05/3813.25/4211.9
  Non-responders21/4052.521/4052.520/3852.620/3852.610/4223.810/4223.8
 Negative (n=60)
  BacC17/2085.013/2065.018/2281.811/2250.016/1888.913/1872.2
  NewInf4/2020.07/2231.83/1816.7
  Non-responders3/2015.03/2015.04/2218.24/2218.22/1811.12/1811.1
Day 28
 Positive (n=120)
  BacC13/39†33.39/3923.117/3844.713/3834.225/4259.523/4254.8
  NoBacC2/395.12/395.10/380.00/380.02/424.82/424.8
  NewInf4/3910.24/3810.52/424.8
  Non-responders24/3961.524/3961.521/3855.321/3855.315/4235.715/4235.7
 Negative (n=60)
  BacC15/19†78.913/1968.416/2272.714/2263.613/17†76.510/1758.8
  NewInf2/1910.52/229.13/1717.6
  Non-responders4/1921.14/1921.16/2227.36/2227.34/1723.54/1723.5
  • Results are given in number of total cures out of cases treated (n/n) and in % of all cases treated.

  • *Evaluation criteria according to EMEA or DVG.

  • †Early culling of one cow due to different reasons (dangerous handling, lameness, fertility disorder).

  • BacC, bacteriological cure (elimination of the pathogen present on day 0); DVG, German Veterinary Association; EMEA, European Agency for the Evaluation of Medicinal Products; NewInf, newly infected udder quarter (pathogen was different from the one on day 0); NoBacC, no bacteriological cure (the pathogen on day 0 was still present in the udder); non-responders, cows with no clinical cure were rated as non-responsive to the treatment given.