| Total mgs | = (Total mls, number or kg of product sold or used) x (mg/ml, mg/unit or mg/kg) |
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Total mg/kg
(sometimes called mg/PCU if the standard weight of 425 kg is used) | =Total use (mg)/total wt of cattle at risk of treatment (kg)
(total use (mg) defined as above) |
Total mg of each active substance used Number of cattle at risk of treatment Cattle weight (can be ESVACdefined (425 kg) or country-specific or unit-specific)
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6
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Daily dose metrics
(eg, DDDvet) | =Total use (mg) / (daily dose (mg/kg) x total weight of cattle at risk of treatment (kg))
The calculation is carried out for each AM category and added together to get the total figure.*
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Total mg of each active substance used Daily dose per kg*—these can be ESVAC-defined, or country-specific or unit-specific Number of cattle at risk of treatment Cattle weight (can be ESVAC-defined (425 kg) or country-specific or unit-specific)
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Takes into account animal weight and number of cattle Takes into account dose rate differences across AMs ESVAC-supported Dose and cattle weight can be made specific to country or unit which improves accuracy and comparability
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More complicated to calculate than mg and mg/kg metrics If using standardised weights and/or defined dose rates, these may not be accurate for a particular country or unit Assumptions rely on knowledge of certain aspects of medicine pharmacokinetics that are not necessarily known (eg, the exact duration of action) Does not take into account different course lengths across AMs Some drugs or routes of administration do not have defined dose values
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11
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Course dose metrics
(eg, DCDvet) | =Total use (mg) / (course dose (mg/kg) x total weight of cattle at risk of treatment (kg))
The calculation is carried out for each AM category and added together to get the total figure. |
Total mg of each active substance used Daily course per kg—these can be ESVAC-defined, or country-specific or unit- specific Number of cattle at risk of treatment Cattle weight (can be ESVAC-defined (425 kg) or country-specific or unit-specific)
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Takes into account animal weight and number of cattle Takes into account dose rate and course length differences across AMs ESVAC-supported Dose, course and cattle weight can be made specific to country or unit which improves accuracy and comparability
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More complicated to calculate than mg and mg/kg metrics If using standardised weights and/or defined dose rates and course lengths, these may not be accurate for a particular country or unit Assumptions rely on knowledge of certain aspects of medicine pharmacokinetics that are not necessarily known (eg, the exact duration of action)
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11
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| Cow calculated courses (CCC) | =Number of courses in 12 months / number of cattle on the holding |
Number of courses used on the farm (calculated from quantity of each medicine used on farm and the quantity required per course) Number of cattle at risk of treatment, split into youngstock (<24 months) and adult (>24 months)
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Takes into account number of cattle and can use specific weights Takes into account course differences across AMs Takes into account youngstock use (and can separate use in youngstock from use in adults)
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Requires information on the number of youngstock as well as the number of adult dairy cattle If using standardised weights (100 and 600 kg) and/or defined dose rates and course lengths, these may not be accurate for a particular country or unit Medicines are assigned only for youngstock or only for adults, which may not be accurate
| T. Clarke, personal communication |