TABLE 5:

Behavioural sum scores by time point

Time pointDexmedetomidine (n=89)Placebo (n=93)
Mean (n)Change from predoseMean (n)Change from predose
Screening (previous New Year's Eves)18.7 (89)19.1 (93)
Baseline (2 days before New Year's Eve)0.8 (89)1.3 (93)
First dose
 Predose4.9 (89)5.1 (93)
 One-hour postdose3.8 (89)−1.14.7 (93)−0.5
Second dose
 Predose9.1 (75)10.0 (78)
 One-hour postdose4.5 (74)−4.78.8 (78)−1.2
Third dose
 Predose9.8 (49)13.3 (51)
 One -hour postdose6.3 (48)−3.610.0 (50)−3.1
Fourth dose
 Predose7.5 (17)12.0 (24)
 One-hour postdose6.2 (16)−1.412.0 (23)−0.6