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Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry
  1. M. Davies, BVetMed CertVR CertSAO FRCVS1,
  2. J. West, BVMBVS2,
  3. C. Williams, PhD2 and
  4. D.S. Gardner, DSc2
  1. 1Provet Limited, The Old School House, 7 Church lane, Ravenfield, South Yorkshire S65 4NG, UK
  2. 2School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12, UK
  1. E-mail for correspondence: mikedaviesvet{at}gmail.com

Abstract

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85–7.70] v MCPD, 4.30 [3.25–6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies.

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