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Susceptibility and PK/PD relationships of Staphylococcus aureus strains from ovine and caprine with clinical mastitis against five veterinary fluoroquinolones
  1. J. M. Serrano-Rodríguez, ChemD, PhD1,
  2. C. Cárceles-García, MD, PhD2,
  3. C. M. Cárceles-Rodríguez, DVM, PhD2,
  4. M. L. Gabarda, PharmD, PhD2,
  5. J. M. Serrano-Caballero, DVM, PhD1 and
  6. E. Fernández-Varón2
  1. 1 Department of Pharmacology, Toxicology and Legal and Forensic Medicine, Faculty of Veterinary Medicine, University of Cordoba, Campus de Rabanales, Córdoba 14.071, Spain
  2. 2Department of Pharmacology. Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, Murcia 30.071, Spain
  1. E mail for correspondence: emiliofv{at}um.es

Abstract

Minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) of veterinary fluoroquinolones as enrofloxacin, its metabolite ciprofloxacin, danofloxacin, difloxacin and marbofloxacin against Staphylococcus aureus strains (n=24) isolated from milk of sheep and goats affected by clinical mastitis were evaluated. The authors have used the MIC and MPC, as well as the pharmacokinetic-pharmacodynamic relationships in plasma and milk. MIC values were significantly different between drugs, unlike MPC values. Lower MIC values were obtained for danofloxacin and difloxacin, middle and higher values for enrofloxacin, ciprofloxacin and marbofloxacin. However, differences in MPC values were not found between drugs. At conventional doses, the AUC24/MIC and AUC24/MPC ratios were close to 30–80 hours and 5–30 hours, with exception of danofloxacin, in plasma and milk. The time inside the mutant selection window (TMSW) was close to 3–6 hours for enrofloxacin, ciprofloxacin and marbofloxacin, near to 8 hours for danofloxacin and 12–22 hours for difloxacin. From these data, the mutant selection window could be higher for danofloxacin and difloxacin compared with the other fluoroquinolones tested. The authors concluded that enrofloxacin and marbofloxacin, at conventional doses, could prevent the selection of bacterial subpopulations of S aureus, unlike danofloxacin and difloxacin, where higher doses could be used.

  • Mutant prevention concentration
  • Fluoroquinolones
  • Mastitis
  • Staphylococcus aureus
  • Lactating sheep
  • Lactating goats
  • Accepted January 22, 2017.

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