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Canine atopic dermatitis reduces the risk of multicentric B cell lymphoma
  1. A. Imai, DVM1 and
  2. D. Santoro, DVM, MS, DrSC, PhD, DipACVD, DipECVD2
  1. 181-7 Oyaguchi Kitamachi, Itabashiku, Tokyo 173-0031, Japan
  2. 2Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, Illinois, 61802, USA
  1. E-mail for correspondence: dsantoro{at}

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CANINE atopic dermatitis (AD) has been defined as ‘a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features associated with IgE antibodies most commonly directed to environmental allergens’ (Halliwell 2006). Due to numerous similarities, several studies have demonstrated the usefulness of the canine animal model for human AD (Marsella and Girolomoni 2009, Olivry 2012).

In people, conflicting results have been published on the association between AD and the development of neoplasia; some studies suggest a protective effect of AD against the development of neoplasia due to a possible enhancement of the immune surveillance. Contrary, other studies have hypothesised that a chronic immune stimulation is at the base of the development of neoplastic diseases in people (Vena and others 1985, Hagstromer and others 2005, Wang and Diepgen 2005).

Recently, canine lymphomas have been established as a model for non-Hodgkin's lymphomas (NHLs) in people due to the striking similarities in clinical presentation, genomic instability, and cytological and histological features (Vail and others 2009, Marconato and others 2013). The most common NHL in dogs is multicentric B cell lymphoma (ML) (Teske 1994). Although a high incidence of AD and ML is present in dogs, no studies have been published on the possible association between these two disorders. Therefore, based on the similarities between canine and human AD and NHL, the goal of this study is to explore the association between canine AD and ML.

Medical records of dogs diagnosed with …

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