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Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic dogs: a randomised, controlled, double-blinded trial
  1. M. Eichenseer, Dr.med.vet.,
  2. C. Johansen, Dr.med.vet. and
  3. R. S. Mueller, Prof. Dr.med.vet., MANZCVSc (Canine Medicine), DipACVD, FANZCVSc (Dermatology), DipECVD
  1. Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, Munich 80539, Germany
  1. E-mail for correspondence: r.mueller{at}lmu.de

Abstract

Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs. Unfortunately, their clinical benefit is largely unsubstantiated. In a double-blinded, placebo-controlled, cross-over trial, the influence of dimetinden and of a combination of chlorpheniramine and hydroxyzine on pruritus and lesions was evaluated in 19 dogs. They were treated with either product or a placebo orally for 14 days, each time followed by a 14-day washout period. Before and after each period, the dogs were examined and the Canine Atopic Dermatitis Extent and Severity Index (CADESI) determined by a clinician, and the pruritus and general condition by the owner. Dimetinden improved the pruritus significantly (P=0.014) but not the CADESI (P=0.087), the combination of hydroxyzine and chlorpheniramine improved the CADESI (P=0.049) and pruritus (P=0.05) significantly. Ten of 17 dogs improved by more than 25 per cent in pruritus with the combination of hydroxyzine and chlorpheniramine, 12 of 18 with dimetindenmaleate and only 2 of 19 with placebo. Antihistamines can help to reduce pruritus in atopic dogs, but in most cases, the improvement is limited and additional treatment may be needed.

  • Allergy
  • Atopy
  • Dogs
  • Clinical trials
  • Treatment
  • Accepted September 18, 2013.

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