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Oxidative stress is an imbalance between free radical production and antioxidant defence. It causes the cellular and extracellular redox state to be shifted to the oxidative side by the disruption of balance between the generation of reactive oxygen species and their elimination (Sies 1997). A previous study in pigs has suggested that exposure to volatile anaesthetics can induce oxidative stress (Allaouchiche and others 2001). Oxidative stress resulting from an imbalance between radical generating and radical scavenging systems is one of the harmful effects related to volatile anaesthesia (Sinclair and others 1990). Moreover, the inhalation of volatile anaesthetics during mechanical ventilation can augment gene expression of proinflammatory cytokines in alveolar macrophages (Kotani and others 1999).
Isoflurane is a volatile anaesthetic that is widely used in veterinary practice, and isoflurane-induced liver damage is much rarer than hepatotoxicity after exposure to other inhaled anaesthetics, such as halothane (Kenna and Jones 1995). However, there are a few reports about the effect of isoflurane on oxidative stress, and the oxidant and antioxidant status of isoflurane in dogs has not been evaluated. Therefore, our purpose was to evaluate the effects of isoflurane on the oxidant and antioxidant status in dogs.
Twelve beagle dogs (ten males and two females), between four and six years of age, weighing between 7 and 12 kg were used All dogs were determined to be healthy on the basis of clinical examinations. Complete blood count, the serum biochemistry and urinalysis profiles were within reference ranges. The experimental and housing protocols were approved by the Animal Care and Use Committee of Chungnam National University (Approval No. CNU- 00043). Food was withheld for 6–10 hours prior to anaesthesia, but access to water was allowed. Anaesthesia …