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Urine concentrations of oxalate and calcium play an important role in calcium oxalate (CaOx) urolith formation in dogs and cats, with high excretions of both substances increasing the chance of CaOx urolithiasis. In 17 CaOx-forming dogs, urine calcium:creatinine ratio (Ca:Cr) was found to be increased compared with healthy control dogs, whereas urine oxalate:creatinine ratio (Ox:Cr) did not differ (Stevenson and others 2004). In six CaOx-forming miniature schnauzers, urinary calcium excretion (in mg/kg/24 hours) was increased compared with healthy controls, while urinary oxalate excretion was not affected (Lulich and others 1991). However, in these studies, the urine samples were not always collected at the time CaOx uroliths were actually present in the urinary tract. Moreover, in these studies, individual urinary oxalate and calcium excretions were mostly not provided.
The objective of this study was to determine the urinary oxalate and calcium excretion rates, and the urinary calcium to oxalate ratio (Ca:oxalate), at the time CaOx uroliths were present in the urinary tract of dogs and cats.
Materials and Methods
Data for this observational study were collected through urine sampling and questionnaires from May 2010 to January 2012.
Participation in this study was voluntary, and informed consent was obtained from dog and cat owners who consulted the University Clinic for Companion Animals of the Utrecht University because of urolithiasis. Dogs and …