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Haptoglobin concentration in galgos and greyhounds
  1. S. Zaldívar-López1,
  2. I. Mesa-Sánchez2,
  3. A. Galán-Rodríguez2,
  4. J. J. Cerón3,
  5. S. Martínez-Subiela3,
  6. M. M. Granados-Machuca2 and
  7. C. G. Couto1
  1. Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA
  2. Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain
  3. Animal Medicine and Surgery, University of Murcia, Spain
  1. E-mail for correspondence sara.zaldiv{at}gmail.com

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Greyhounds and galgos Españoles (Spanish greyhounds, GEs) share common origins, and are thus closely related breeds (same breed group and section, according to the Fédération Cynologique Internationale).

Clinicopathological peculiarities of greyhounds have been extensively studied over the last decade. These haematological, haemostatic and biochemical idiosyncrasies have been recently reviewed (Zaldivar-Lopez and others 2011). Despite the similarities between GEs and greyhounds, there are selected phenotypical and physiological differences between them. For example, while greyhounds have a very low frequency of dog erythrocyte antigen 1.1 on the surface of the red blood cells (<15 per cent) (Iazbik and others 2010), GEs have a high frequency (>30 per cent) (Mesa and others 2009).

In 2009, the authors reported that greyhounds have lower serum haptoglobin (Hp) concentrations than non-greyhound dogs; Hp was measured by colorimetric and immunoturbidimetric methods, and confirmed through electrophoresis (Couto and others 2009). Besides systemic immunomodulatory effects (ie, fever, leucocytosis, etc), acute phase response includes changes in the concentrations of acute phase proteins (APPs), which are classified as negative (downregulated) or positive (upregulated). Hp is a positive APP, whose concentration increases rapidly in response to inflammation or tissue injury (Martinez-Subiela and others 2002), in order to remove the noxious stimuli, and restore homeostasis. Hp also acts as a free haemoglobin (Hb) scavenger, preventing tissue oxidative damage and renal dysfunction (Nielsen and others 2010), and has bactericidal effect in infected wounds (by limiting the availability of iron for bacterial growth through Hb-binding) (Murata and others 2004). Hp in dogs is a moderate APP (Conner and others 1988), and changes in concentration have been shown to be of diagnostic and prognostic value in inflammatory processes, such as infectious diseases (leishmaniosis (Martinez-Subiela and others 2002), trypanosomiasis (Ndung'u and others 1991) and after surgical trauma (Ceron and others 2005).

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