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Staphylococcus aureus is one of the most important pathogenic Staphylococcus species in veterinary medicine. In rabbits, it mainly causes skin infections, pododermatitis and mastitis with subsequent economic losses in industrial rabbit farms (Hermans and others 1999).
Fluoroquinolones are antimicrobial drugs which generally have very good activities against a broad spectrum of aerobic bacteria, including Pasteurella species, and mycoplasma (Walker 2000). The main target site for its bactericidal action is the deoxyribonucleic acid (DNA)-gyrase. This enzyme is required for supercoiling of DNA to provide spatial arrangement of DNA in the bacterial cell. Furthermore, fluoroquinolones have other beneficial characteristics such as large volumes of distribution, low plasma protein binding and relatively low minimum inhibitory concentrations (MICs) against susceptible target microorganisms (Brown 1996). Marbofloxacin (MAR) and enrofloxacin (ENR), are relatively new synthetic fluoroquinolone antimicrobial drugs which have been developed especially for using in veterinary medicine, and they could be potentially useful in rabbits.
Therefore, this study was designed to evaluate the degree of in vitro activity of MAR and ENR against 27 S aureus strains isolated from rabbits with chronic problems of staphylococcosis in Spain.
A total of 27 S aureus strains were isolated from commercial rabbit farms …