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Comparison of a chlorhexidine and a benzoyl peroxide shampoo as sole treatment in canine superficial pyoderma
  1. A. Loeffler, DrMedVet, PhD, DVD, DipECVD, MRCVS1,
  2. M. A. Cobb, MA, VetMB, PhD, MBA, DVC, MRCVS2 and
  3. R. Bond, BVMS, PhD, DVD, DipECVD, MRCVS1
  1. Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, North Mymms, Hertfordshire AL9 7TA, UK
  2. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
  1. E-mail for correspondence aloeffler{at}

The clinical and antibacterial efficacy of two shampoos used as a sole antibacterial treatment in dogs with superficial pyoderma were investigated and compared. In a randomised, partially blinded study, a 3 per cent chlorhexidine gluconate shampoo (Chlorhex 3; Leo Animal Health) was compared against a 2.5 per cent benzoyl peroxide shampoo (Paxcutol; Virbac) in 22 dogs with superficial pyoderma. Dogs were washed two to three times weekly with a 10-minute contact time over 21 days. Clinical scores and bacterial counts were assessed on days 1, 8 and 22 and compared within and between treatment groups; overall response was assessed at the end of the study. Twenty dogs completed the study; 15 (68.2 per cent) showed an overall clinical improvement and the clinical signs resolved in three chlorhexidine-treated dogs. In the chlorhexidine-treated group, scores for papules/pustules (P<0.001), investigator-assessed pruritus (P=0.003), total bacterial counts (P=0.003) and counts for coagulase-positive staphylococci (P=0.003) were reduced after three weeks. Scores and bacterial counts did not vary significantly in the benzoyl peroxide-treated group.

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  • Provenance not commissioned; externally peer reviewed

  • Conflict of interest AL's Senior Clinical Scholarship at the Royal Veterinary College was partially funded by Leo Animal Health between 2001 and 2004. MC was an employee of Leo Animal Health when this study was conducted.

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