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Thromboelastographic changes after gonadectomy in retired racing greyhounds
  1. P. Vilar Saavedra, DVM, MS1,
  2. N. Stingle, LVT1,
  3. C. Iazbik, DVM1,
  4. L. Marín, DVM1,
  5. M. A. McLoughlin, DVM, MS, DiplACVS1,
  6. Y. Xie2 and
  7. G. Couto, DVM, DiplACVIM1
  1. Department of Veterinary Clinical Sciences and Veterinary Teaching Hospital, Ohio State University, Columbus, Ohio 43210, USA
  2. Center for Statistical Training & Consulting, Michigan State University, East Lansing, Michigan 48824, USA
  1. Correspondence to psaavedr{at}cvm.msu.edu
  • Dr Saavedra's present address is the Department of Small Animal Clinical Sciences and Veterinary Teaching Hospital, Michigan State University, East Lansing, Michigan 48824, USA

  • Dr Couto is also at OSU Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA

Twenty-one healthy greyhounds with no history or clinical signs of bleeding disorders, and no abnormalities on physical examination, complete blood count, serum biochemistry profiles (in dogs more than five years of age), and SNAP-4DX test for vector borne diseases underwent routine gonadectomies at the Ohio State University Veterinary Teaching Hospital. Blood samples were collected 24 hours before and after surgery by jugular venepuncture for thromboelastography and haemostasis assays (prothrombin time [PT], activated partial thromboplastin time [aPTT], fibrinogen concentration). The magnitude of the bleeding in each patient was estimated using a bleeding scoring system recently validated in greyhounds. Eight dogs were classified as bleeders and 13 as non-bleeders. Thromboelastograph (TEG) tracings in bleeders were different to that of non-bleeders. Neither sex (odds ratio [OR]: 0.148, P=0.05), haematocrit (OR: 0.907, P=0.39), platelet count (OR: 0.996, P=0.65) or age (OR: 0.949, P=0.83) were predictors of the outcome. None of the variables that evaluated clot kinetics, and fibrinolysis (that is, aPTT OR: 0.781, P=0.51; PT OR: 1.337, P=0.63; TEGR OR: 1.269, P=0.06; TEGK OR: 1.696, P=0.05; TEGLY60 OR: 1.028, P=0.81) were able to predict the bleeding episodes. Only the TEG variables that represent the fibrin cross-linking of the clot (TEGangle OR: 0.903, P=0.03); and the strength of the clot (TEGMA OR: 0.833, P=0.03) were considered predictors of the outcome.

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  • Provenance not commissioned; externally peer reviewed

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