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Pharmacokinetics of a single oral administration of cefalexin in mares and foals
  1. G. J. B. Ladaga, DVM1,
  2. F. P. Lezica, DVM2,
  3. A. M. Barboni, PhD3,
  4. J. A. Picos, PhD3 and
  5. G. A. de Erausquin, MD, PhD, MSc4
  1. Department of Research and Development, Laboratorio Fundación, Buenos Aires, Argentina
  2. Haras La Pasión, San Antonio de Areco, Buenos Aires, Argentina
  3. Cátedra de Enfermedades Infecciosas, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina
  4. Laboratory of Brain Development, Modulation and Repair, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachussets, USA
  1. Correspondence to Dr de Erausquin, email: gdeerausquin{at}partners.org

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CEFALEXIN is a first-generation broad-spectrum cephalosporin with well-documented efficacy in experimental and clinical studies in human (Clark and Turck 1968, Levison and others 1969, Thornhill and others 1969, Speight and others 1972) and veterinary (Ling and Ruby 1983, Crosse and Burt 1984a, Silley and Brewster 1988, Lees and others 1990) medicine. Its pharmacokinetics in horses has been studied after intravenous or intramuscular (Lees and others 1990, Villa and others 2002), but not oral administration. The comparative pharmacokinetics of adult horses and foals are not available. This study reports pharmacokinetic data following a single oral dose of cefalexin to mares and foals.

Four healthy, non-pregnant five-year-old thoroughbred mares, weighing 400 to 450 kg, and four unrelated three-month-old suckling female thoroughbred foals, weighing 140 to 160 kg, were included in the study. All the animals were grazed on pasture and had access to water ad libitum, and the foals had free access to their mothers.

A single oral dose of 30 mg/kg cefalexin monohydrate in the form of crushed tablets (Cefoxidin; Laboratorio Fundación) mixed with honey was administered.

Blood samples (10 ml) were collected from …

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