Article Text

Treatment of canine oral papillomatosis

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Clinical scenario

An 11-month-old male, neutered crossbreed is presented to you with a five-month history of grey, pedunculated cauliflower-like lesions in its oral cavity; histopathological findings were consistent with a diagnosis of oral papillomatosis. The owner was previously told that the lesions are due to viral infection and that they would spontaneously regress over four to eight weeks, but they have persisted, are now more extensive and the dog is reluctant to eat.

The question

In [dogs diagnosed with canine oral papillomatosis that has not spontaneously regressed within four to eight weeks], is the use of [recombinant feline interferon-ω (Virbagen Omega; Virbac)] more effective compared with treatment with [azithromycin (Zithromax; Pfizer)] in achieving [clinical resolution]?

Is azithromycin an effective treatment option for dogs with oral papillomatosis?

Search parameters

The search parameters are available as a supplement to this article on Veterinary Record’s website at

Search outcome

  • Nine papers found in CAB search

  • No relevant papers were found from CAB

  • Thirteen papers found in Medline search

  • One paper was excluded as it was a review paper

  • One total relevant paper from Medline

  • Five papers found in Web of Science search

  • One paper was excluded as it didn’t answer the question

  • One total relevant paper from Web of Science (the same paper as found in Medline search)

  • Three total relevant papers. The second paper was found from a wider online search and the third paper was identified from examination of a review paper (Nagata and Rosenkrantz 2013).

Search last performed

May 9, 2017

Summary of evidence

Paper 1: Azithromycin therapy of papillomatosis in dogs: a prospective, randomised, double-blinded, placebo-controlled clinical trial (Yagci and others 2008).

Patient group: A total of 17 dogs with papillomas (12 with oral papillomas and five with cutaneous papillomas), 13 of which were pure breeds and four of which were crossbreeds. The dogs were randomly assigned a treatment group by …

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