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An 11-month-old male, neutered crossbreed is presented to you with a five-month history of grey, pedunculated cauliflower-like lesions in its oral cavity; histopathological findings were consistent with a diagnosis of oral papillomatosis. The owner was previously told that the lesions are due to viral infection and that they would spontaneously regress over four to eight weeks, but they have persisted, are now more extensive and the dog is reluctant to eat.
In [dogs diagnosed with canine oral papillomatosis that has not spontaneously regressed within four to eight weeks], is the use of [recombinant feline interferon-ω (Virbagen Omega; Virbac)] more effective compared with treatment with [azithromycin (Zithromax; Pfizer)] in achieving [clinical resolution]?
The search parameters are available as a supplement to this article on Veterinary Record’s website at http://veterinaryrecord.bmj.com/content/181/4/92.
Nine papers found in CAB search
No relevant papers were found from CAB
Thirteen papers found in Medline search
One paper was excluded as it was a review paper
One total relevant paper from Medline
Five papers found in Web of Science search
One paper was excluded as it didn’t answer the question
One total relevant paper from Web of Science (the same paper as found in Medline search)
Three total relevant papers. The second paper was found from a wider online search and the third paper was identified from examination of a review paper (Nagata and Rosenkrantz 2013).
Search last performed
May 9, 2017
Summary of evidence
Paper 1: Azithromycin therapy of papillomatosis in dogs: a prospective, randomised, double-blinded, placebo-controlled clinical trial (Yagci and others 2008).
Patient group: A total of 17 dogs with papillomas (12 with oral papillomas and five with cutaneous papillomas), 13 of which were pure breeds and four of which were crossbreeds. The dogs were randomly assigned a treatment group by …