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Assessing oral robenacoxib in controlling perioperative pain in dogs after soft tissue surgery
G. Friton, C. Marie Thompson, D. Karadzovska, S. King, J. N. King
Non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to be effective in controlling postoperative pain in dogs when used either alone or in combination with opioids. Robenacoxib is an NSAID with high selectivity for the cyclooxygenase (COX)-2 isoform – inhibition of COX-2 can provide relief from the clinical signs of inflammation and pain. In view of its pharmacological properties, robenacoxib could provide optimal perioperative pain control in dogs. This study aimed to assess the efficacy and safety of an oral tablet formulation of robenacoxib in dogs undergoing soft tissue surgery.
The randomised, placebo-controlled, clinical trial included 239 dogs that were allocated to receive either robenacoxib or a placebo. Each dog received an oral tablet administration of robenacoxib (at a target dose of 2 mg/kg) or a placebo once before surgery and for two additional days after surgery. All dogs also received a preanesthetic dose of 0.2 mg/kg butorphanol. Pain assessments were performed using the short form of the Glasgow composite measure pain scale. Treatment failure was defined as the need for rescue therapy to control postoperative pain.
Significantly (P=0.019) more dogs administered robenacoxib were considered treatment successes (89 …