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Homocysteine serum concentration associated with severity of mitral valve disease in dogs

C. M. Lee, D. M. Jeong, M. H. Kang, S. G. Kim, J. I. Han, H. M. Park

HOMOCYSTEINE is an essential amino acid metabolite of methionine. Studies have suggested a relationship between increased levels of homocysteine in the blood and cardiovascular disease; however, the mechanism causing the effect is unclear.

Myomatous mitral valve disease (MMVD) is the most prevalent heart disease in dogs; histopathological changes in the mitral valve of dogs with MMVD includes damage to the endothelial cell lining. This study aimed to identify the association between serum homocysteine concentrations in dogs with MMVD and stage of MMVD.

Fifty-three dogs with MMVD and 10 healthy control beagles were included in the study. Dogs with MMVD were allocated to three groups using the staging system of the American College of Veterinary Internal Medicine: dogs with MMVD that had never developed clinical signs caused by heart failure (stage B); dogs with past or current clinical signs of heart failure (stage C); and dogs with end-stage disease with clinical signs of heart failure (stage D). Blood samples were collected from all dogs and serum homocysteine and cardiac troponin …

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