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Oxidative stress in dogs with inflammatory bowel disease
C. P. Rubio, S. Martínez-Subiela, J. Hernández-Ruiz, A. Tvarijonaviciute, J. J. Cerón, K. Allenspach
IDIOPATHIC inflammatory bowel disease (IBS) is the most common cause of chronic intestinal disease in dogs and results in a range of often debilitating clinical signs. The pathogenesis of IBD in dogs is not completely understood; however, there is evidence that oxidative stress (an imbalance between the production of reactive oxygen species and their removal by antioxidants) plays an important role in the pathogenesis of IBD in people.
This study aimed to compare the antioxidant response and oxidative stress response in dogs with and without IBD, using a panel of serum biomarkers.
Serum samples obtained from 18 dogs with IBD and 20 healthy dogs were included in the study. Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine the antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX), thiobarbituric acid reactive substances (TBARS) and reactive oxygen species production (ROS) concentrations in …
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