Article Text

PDF
Review
Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis
  1. E. de Bakker1,
  2. V. Stroobants1,
  3. F. VanDael2,3,
  4. B. Van Ryssen1 and
  5. E. Meyer2,3
  1. 1Department of Medical Imaging and Small Animal Orthopaedics,
  2. 2Department of Pharmacology, Toxicology and Biochemistry,
  3. 3Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
  1. E-mail for correspondence: evelien.debakker{at}ugent.be

Abstract

Secondary, non-inflammatory osteoarthritis (OA) is a common disorder in dogs. Its silent onset prevents early diagnosis and delays treatment. Synovial fluid biomarkers can detect OA at an early stage, before the presence of radiographic signs. In addition, these local biomarkers can aid prognosis of the disease, monitor the response to treatment and can be used to assess the degree of OA. Currently three groups of canine synovial fluid biomarkers have been the focus of research: proinflammatory mediators, enzymes and their inhibitors, and extracellular cartilage degeneration products. These have been investigated in the elbow, hip and stifle joints of both normal dogs and dogs with naturally occurring and experimentally induced OA. None of these biomarkers are currently used in practice for the detection of canine OA at an early stage. A positive relationship between canine synovial fluid biomarkers and OA has been demonstrated, yet no molecular diagnostic test has been developed so far.

  • Dogs
  • Osteoarthritis
  • Synovial fluid
  • Biomarkers
  • Orthopaedics

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.