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Effectiveness of chemotherapy after surgical treatment of osteocarcinoma in dogs
A. F. Schmidt, M. Nielen, S. J. Withrow, L. E. Selmic, J. H. Burton, O. H. Klungel and others
CANINE osteocarcinoma is the most common bone cancer in large purebred dogs. Surgically treated dogs with appendicular osteocarcinoma have a median survival time of five months; however, chemotherapy has been shown to extend this survival. The authors of this study had previously constructed a multivariable prediction tool, which predicted a dog's risk of mortality at five months and one year after surgical treatment for osteocarcinoma. It used factors including age, weight, sex, breed and tumour location. The authors had also shown that chemotherapy was most effective in dogs with a low predicted risk. This present study aimed to validate these findings using an independent cohort study.
A total of 794 dogs that had previously received surgical treatment for osteocarcinoma were used in the study. Along with factors such as age and weight, it was noted if the dogs had received chemotherapy as part of their treatment and whether they were alive or dead at five months and one year. It was found that 163 dogs had not received chemotherapy, 172 received carboplatin, 238 received doxorubicin and in 221 dogs the chemotherapy regime was …