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Diagnostic accuracy of serum total lactate dehydrogenase to differentiate between alimentary lymphoma and IBD in cats

R. Terragni, A. M. Morselli-Labate, M. Vignoli, E. Bottero, B. Brunetti, J. H. Saunders

ALIMENTARY lymphoma is the most common form of lymphoma in cats; however, previous studies may have underestimated its incidence due to the difficulty in distinguishing mucosal T cell lymphoma from lymphoplasmacytic inflammatory bowel disease (IBD). This study aimed to determine whether an elevation of total lactate dehydrogenase (LDH) would be seen in cats with alimentary lymphoma or IBD and to assess whether this test is useful in supporting the differential diagnosis of these diseases.

Seventy-one cats with a history of chronic gastrointestinal clinical signs were included in the study. All the cats had a physical examination and an abdominal ultrasound scan and endoscopic gastrointestinal biopsy were performed to differentiate between cats with alimentary lymphoma (33 cats) and IBD (38 cats). Serum samples of total LDH were evaluated at the time of clinical presentation and after 12 hours of fasting in all cats.

The diagnostic accuracy of serum total LDH in differentiating between cats with alimentary lymphoma and those with IBD was low (62 per cent) and showed poor sensitivity (61 per cent) and specificity (74 per …

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