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WE wish to report a case of cholesterol deficiency (CD), also known as haplotype cholesterol deficiency, in a 56 kg, 19-week-old Holstein-Friesian calf. This condition, caused by a genetic defect, was reported relatively recently in German calves by Kipp and others (2015) who traced the defect to a North American bull, Maughlin Storm, born in 1991 and used extensively in the Holstein population worldwide. The authors reported that, in Germany, the affected calves developed chronic diarrhoea and illthrift, and died from three weeks to six months of age. The defect is only seen clinically in the homozygote form, and although the precise gene, or action of the genes, was (until recently) unclear it causes a fatal inability to maintain a level of blood cholesterol sufficient for …
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