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Evaluation of urinary biomarkers for diagnosing azotaemic chronic kidney disease in cats
T. L. Williams, J. Archer
CHRONIC kidney disease (CKD) is a common condition of geriatric cats which affects up to 31 per cent of cats aged over 15 years. However, routine screening in cats can be expensive and may be perceived as invasive by owners. An automated particle-enhanced turbidimetric assay (PETIA) to measure cystatin C in canine urine has recently been validated which can be performed using standard automated analysers available in many commercial laboratories. The first aim of this study was to validate two PETIAs used in human medicine for measuring urinary albumin and cystatin C in feline urine. Using these assays, the authors then investigated whether the following urinary biomarkers could be used as screening tests for azotaemic CKD in cats: urinary albumin:creatinine ratio (uAlb:Cr), urinary cystatin C:creatinine ratio (uCysC:Cr), urine protein:creatinine ratio (UPC) and urine specific gravity (USG).
Blood and urine samples were obtained from cats over eight years old at three UK first-opinion practices, between March 1, 2013, and April 30, 2015, as part of a free screening programme. Twelve cats were diagnosed with azotaemic CKD and 40 healthy …