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Reported adverse reactions to non-steroidal anti-inflammatory drugs in dogs and cats in the UK

J. R. Hunt, R. S. Dean, G. N. D. Davis, J. C. Murrell

PRESCRIPTION of non-steroidal anti-inflammatory drugs (NSAIDs) is common for perioperative analgesia and management of inflammatory conditions such as osteoarthritis. This study aimed to analyse UK pharmacovigilance data to quantify adverse events associated with NSAIDs. It was hypothesised that the frequency of adverse effects would be lower when associated with cyclo-oxygenase-2 selective (coxib) NSAIDs than with non-selective (non-coxib) NSAIDs.

The study used data supplied by the UK Veterinary Medicines Directorate (VMD) on frequencies of adverse events from its periodic safety update reports. The frequency of adverse events was similar between dogs and cats, at around 0.0003 per cent. The five most reported adverse events were emesis, death, anorexia, lethargy and diarrhoea. The reported frequency of emesis, renal insufficiency and death was higher with injectable NSAIDs than with oral NSAIDs (P=0.043). The reported frequency of emesis, lethargy and death was higher with coxib NSAIDs than with non-coxib NSAIDs (P=0.029).

A negative correlation was observed between the time since authorisation of …

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