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Screening diabetic cats for hypersomatotropism

S. J. M. Niessen, Y. Forcada, P. Mantis, C. R. Lamb, N. Harrington, R. Fowkes and others

NATURALLY occurring diabetes mellitus (DM) is currently estimated to affect approximately 1 in 200 household cats in the UK, and the number is thought to be rising. Feline DM is therefore an important veterinary endocrinopathy, but has also been increasingly studied as a model for human type 2 DM as it shares many characteristics with human DM. Although feline type 2 DM is the most common type of spontaneous DM in cats, other types have been described, particularly DM caused by endogenous overproduction of hormones with an insulin-antagonistic effect, such as cortisol (hyperadrenocorticism) or growth hormone (hypersomatotropism [HS]). This study estimated the prevalence of HS in a large cohort of diabetic cats.

A total of 1221 diabetic cats were screened for HS and were classified as suspected of having HS-induced DM on the basis of elevation of serum total insulin-like growth factor-1 (IGF-1) concentration of above 1000 ng/ml. Owners of cats that had a serum IGF-1 concentration above 1000 ng/ml were then invited to have a pituitary computed tomography (CT) performed on their cat. If the CT proved unremarkable, pituitary magnetic …

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