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Ovine health
Testing sheep for GM2 gangliosidosis
  1. Chris Lewis1,
  2. Mark Wessels2,
  3. Helen Carty3,
  4. Pauline Baird4,
  5. Timothy Cox5,
  6. Begoña Cachón5,
  7. Susan Wang5,
  8. Paul Holmes6,
  9. Adrienne Mackintosh7 and
  10. Francesca Chianini8
  1. 1Fields Farm, Green Lane, Audlem, Cheshire CW3 0ES
  2. 2Finn Pathologists, Weybread, Diss, Norfolk IP21 5TT
  3. 3Ayr Disease Surveillance Centre, Auchincruive, Ayr KA6 5AE
  4. 4Agri-Food and Biosciences Institute, 43 Beltany Road, Coneywarren, Omagh, County Tyrone BT78 5NF
  5. 5Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ
  6. 6AHVLA – Shrewsbury, Kendal Road, Harlescott, Shrewsbury, Shropshire SY1 4HD
  7. 7AHVLA – Carmarthen, Jobs Well Road, Johnstown, Carmarthen SA31 3EZ
  8. 8Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ
  1. e-mail: christopher{at}knightellington.plus.com

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GM2 gangliosidosis (Tay-Sachs disease) in British Jacob sheep was reported in Veterinary Record by Wessels and colleagues (VR, January 4, 2014, vol 174, pp 20-21). These authors described the clinical and pathological findings associated with this disabling disease, which is inherited as an autosomal recessive condition. The exact prevalence of the causal mutation in the UK flock has yet to be determined.

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