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APART from several obvious reasons for failure of triclabendazole to control liver fluke infections, which can be summarised as misdosing, Fairweather (2011) suggested that reduced metabolism, as a result of liver damage, might be important. Following a serious incident of triclabendazole failure in central Wales, we would like to question how far liver damage is relevant in the diagnosis of triclabendazole resistance.
On one farm, an owner treated his sheep with triclabendazole and levamisole (Combinex; Novartis …
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