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Diagnosis of resistance to triclabendazole
  1. E. M. Jones1,
  2. R. Daniel2 and
  3. G. C. Coles3
  1. 1Ddole Road Veterinary Clinic, Llandrindod Wells, Powys LD1 6DF
  2. 2VLA Aberystwyth, Y Buarth, Aberystwyth, Dyfed SY23 1ND
  3. 3School of Veterinary Sciences, University of Bristol, Langford House, Bristol BS40 5DU
  1. e-mail: gerald.c.coles{at}

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APART from several obvious reasons for failure of triclabendazole to control liver fluke infections, which can be summarised as misdosing, Fairweather (2011) suggested that reduced metabolism, as a result of liver damage, might be important. Following a serious incident of triclabendazole failure in central Wales, we would like to question how far liver damage is relevant in the diagnosis of triclabendazole resistance.

On one farm, an owner treated his sheep with triclabendazole and levamisole (Combinex; Novartis …

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