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WHAT is describes as ‘the most comprehensive understanding yet’ of the action of anthelmintic drugs against parasitic nematodes has been achieved as a result of work to sequence the genome of the barber pole worm, Haemonchus contortus.
Writing in the journal Genome Biology, an international team of researchers describe how they sequenced the genome of a strain of H contortus that was susceptible to all major classes of anthelmintic. They identified genes involved in parasite-specific activities, such as blood feeding, neurological function and drug metabolism. They also described complete gene repertoires for known drug target families, …
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