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AS part of its pharmacovigilance obligations, Pfizer Animal Health has been involved in a number of investigations over the past six months involving suspected lack of efficacy to both live attenuated and inactivated infectious bovine rhinotracheitis (IBR) vaccines. In all cases, the investigations have been triggered by reports of cows showing signs of respiratory disease suspected to be IBR and a higher than expected incidence of cows culled due to chronic pneumonia, despite on-label vaccination programmes. Standard investigations offered have included postmortem examination, bacteriology and virology of nasal/nasopharyngeal swabs, bronchoalveolar lavages (BAL) and paired serology. In addition to IBR, we have screened routinely for respiratory syncytial virus, phosphatidylinositide 3-kinases, bovine viral diarrhoea (BVD) and Mycoplasma bovis. …
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