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Antagonistic effect of different bacteria on Clostridium botulinum types A, B, D and E in vitro
  1. A. Shehata, Dr.Vet.Med.1,2,3,
  2. W. Schrödl, Dr.Vet.Med.1,
  3. J. Neuhaus, BSc1 and
  4. M. Krüger, Prof. Dr.Vet.Med.1
  1. 1Faculty of Veterinary Medicine, Institute of Bacteriology and Mycology, Leipzig University, Leipzig, Germany
  2. 2Poultry and Rabbit Diseases Department, Faculty of Veterinary Medicine, Minoufiya University, Minoufiya, Egypt
  3. 3Albrecht Daniel Thaer-Institute of Agronomy at the University of Leipzig, Leipzig, Germany
  1. E-mail for correspondence: e-mail: shehata{at}

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Clostridium botulinum is an anaerobic, Gram-positive, spore-forming rod that produces a potent neurotoxin. Seven types (A, B, C1+2, D, E, F and G) of C botulinum are recognised, based on the antigenic specificity of the botulinum neurotoxin (BoNT) produced by each strain. Types A, B, E and F cause human botulism, while types B, C and D cause disease in farm animals (Goonetilleke and Harris 2004, Simpson 2004, Radostits and others 2007, Popoff and Bouvet 2009). Animals most commonly affected are wild fowl and poultry, cattle, horses and some species of fish. There are three major recognised disease entities in humans, food-borne botulism, infant botulism and wound botulism. Recently, Rodloff and Krüger (2012) suggested that a new form of chronic, visceral botulism may exist that affects both human beings and animals. The antagonism between C botulinum and bacterial members of the microecosystem …

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