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Effects of canine atopic dermatitis treatments on glucose homeostasis

M. Kovalik, K. L. Thoday, H. Evans, A. H . M. van den Broek, R. J. Mellanby

CANINE atopic dermatitis is a genetically predisposed inflammatory and pruritic skin disease. Treatments include topical glucocorticoids, oral glucocorticoids (prednisone, prednisolone and methylprednisolone), and calcineurin inhibitors (ciclosporin A [CsA] and topical tacrolimus), although some side effects are common. One potential consequence of oral glucocorticoids and CsA treatments is a negative influence on glucose metabolism. The aim of this study was to assess the effects of a standard therapeutic protocol of prednisolone on glucose homeostasis in atopic dogs and to compare it with previously published data for CsA.

Sixteen dogs were treated with prednisolone and these were matched to a previous group of 16 dogs treated with CsA. Glucose metabolism was assessed by measurement of serum insulin, albumin and fructosamine concentrations, and plasma glucose concentrations, before treatment and six weeks afterwards. The response to treatment was assessed by scoring lesions on the dogs at day 0 and day 42 using the canine atopic dermatitis extent and severity index (version 3) and by owner assessment using the Edinburgh Pruritus Scale. …

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