Veterinary Record 171:527 doi:10.1136/vr.100811
  • Research
  • Papers

Systemic or intrasynovial medication as singular or as combination treatment in horses with (peri-)synovial pain

  1. P. R. van Weeren, DVM, PhD, Dipl. ECVS
  1. Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 112-114, Utrecht NL-3584 CM, The Netherlands
  1. E-mail for correspondence: H.Brommer{at}


Records of lame horses (2004–2007) with (peri-)synovial pain of the metacarpophalangeal joint (MCPJ, n = 53), digital flexor tendon sheath (DFTS, n = 20), and distal interphalangeal joint (DIPJ, n = 31) were evaluated (n = 104). Cases were grouped according to the following treatments: (1) systemic administration of NSAIDs (n = 40); (2) intrasynovial administration of glucocorticosteroids (n = 30); (3) combination treatment (n = 34). Outcome was defined as successful when the owner reported that the horse had returned to its previous level of performance within a period of up to six months after treatment. Statistical evaluation was performed using Fisher's Exact tests and multivariable logistic regression analyses at P < 0.05. Successful outcome was significantly higher for horses in treatment group 3 (19/34, 55.9 per cent, P = 0.021) than in treatment groups 1 (11/40, 27.5 per cent, OR 0.21, 95 per cent CI 0.06 to 0.71) and 2 (8/30, 26.6 per cent, OR 0.18, 95 per cent CI 0.06 to 0.56). A significant association was only found with regard to the affected synovial structure (P = 0.025); relative to the DIPJ, involvement of the MCPJ and DFTS was four to five times more likely to provide a successful outcome (OR 4.18 and 5.59, 95 per cent CI 1.24 to 14.08 and 1.42–22.22, respectively).

  • Accepted September 21, 2012.
  • Published Online First 23 October 2012

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