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CONTAGIOUS bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subspecies mycoides SC, is one of the most important cattle diseases in many countries of sub-Saharan Africa. Traditionally, CBPP has been controlled by the live T1/44 vaccine, which has been used in Africa for over 60 years. Vaccination has been shown to be successful when coverage of the cattle population of a country or region is high and maintained over successive years. However, it is well known that the vaccine provides only short-term immunity, can cause severe adverse reactions and is rarely effective in the face of a severe outbreak. Furthermore, mathematical modelling has shown that even a mass vaccination campaign over a five-year period is unlikely to achieve eradication unless other strategies are also used (Mariner and Catley 2004). Previously, it was believed …
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