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Biomarkers in dogs surgically treated for ruptured cranial cruciate ligaments
  1. Y. Fujita,
  2. Y. Hara,
  3. Y. Nezu,
  4. H. Orima and
  5. M. Tagawa
  1. 1Laboratory of Surgery II, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 2525201, Japan
  2. 2Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 1808602, Japan
  3. 3Division of Veterinary Radiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 1808602, Japan
  1. E-mail for correspondence: fujita{at}azabu-u.ac.jp

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Thirty-one dogs with cranial cruciate ligament rupture (CCLR) were randomly treated with tibial plateau levelling osteotomy (TPLO; TPLO group) or proximal tibial osteotomy (PTO; PTO group). Synovial fluid was collected once before surgery and at one, two, three and six months after surgery. Cytokine activities (interleukin-1β, interleukin-6 and tumour necrosis factor-α) were determined by bioassays. Matrix metalloproteinase -3 activity was measured using a fluorogenic substrate. Sulphated glycosaminoglycan contents were determined by a dimethylmethylene blue dye-binding assay. Mediolateral and craniocaudal radiographs were obtained before surgery and at three and six months after surgery. Radiographic osteoarthritis findings were scored. Cytokine activities in the TPLO group appeared to decrease more quickly following surgery than those in the PTO group. At six months postoperatively, the progression of radiographic osteoarthritis score in the TPLO group was significantly lower than that in the PTO group. According to these results, joint inflammation in the stifle joints with CCLR could be reduced in the earlier postoperative period by performing TPLO, and TPLO could delay the progression of the radiographic findings of osteoarthritis, compared with PTO. TPLO may be an effective surgical procedure in the prevention of osteoarthritis progression in the stifle joints in dogs with CCLR.

CCLR is one of the most common injuries in dogs and is the major cause of osteoarthritis in the stifle joint (Johnson and others 1994). The purposes of the surgical treatment of CCLR are to stabilise the stifle joint, to prevent secondary meniscal damage, and to inhibit the progression of osteoarthritis (Piermattei and others 2006). Intra- or extra-articular reconstructions of the cranial cruciate ligament (CCL) and corrective osteotomies of the tibia have been performed in dogs with CCLR. The main purpose of corrective osteotomies of the tibia is to provide functional stifle joint stability during the stance phase of the gait cycle …

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