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Assessing a chemotherapy protocol in the treatment of appendicular osteosarcoma in dogs

A. Lane, M. Black, K. Wyatt

Osteosarcoma of the appendicular skeleton is the most common primary bone tumour in dogs. It is a very aggressive neoplasm and most dogs develop metastatic disease. The current standard of care, aimed at controlling the primary tumour and the microscopic metastatic disease, involves limb amputation or limb-sparing surgery followed by adjuvant chemotherapy. This retrospective study aimed to evaluate the safety and efficacy of a novel doxorubicin and carboplatin chemotherapy protocol for the treatment of appendicular osteosarcoma following limb amputation.

Dogs diagnosed with appendicular osteosarcoma, with no evidence of metastatic disease, treated with amputation and adjuvant chemotherapy – consisting of two doses of doxorubicin given 14 days apart followed by four doses of carboplatin at three weekly intervals – were identified from the medical records of Perth Veterinary Oncology (Australia) between September 2003 and December 2009. Haematological and gastrointestinal toxicities were assessed based on information in medical records. The efficacy of the treatment was assessed by determining the median disease-free interval (DRI) and the overall survival time (OST).

A total of 33 dogs met the inclusion criteria. The median DFI was 231.5 days and the median OST was 247 days. Haematological toxicity assessment showed 56 per …

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