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Dust constituents and their effect on canine atopic dermatitis
F. A. Looringh van Beeck, H. Hoekstra, B. Brunekreef, T. Willemse
THIS study measured indoor exposure levels of house dust mite allergens, endotoxins and fungal glucans to determine their possible association with canine atopic dermatitis (CAD).
Dust samples were analysed from households with an adult labrador retriever with CAD (28 dogs) or without CAD (65). Samples were collected between March and October 2007 from the owner's living room floor and from the dog's bedding and coat, using nylon sampling socks and a vacuum cleaner. Samples were analysed to determine levels of house dust mite allergens Der p1 and Der f1, endotoxin and (1→3)-b-D-glucan. All owners completed a questionnaire on household characteristics and their dog's health and housing conditions.
Living room conditions were not significantly different between the two groups. The number of samples with detectable levels of Der p1 was higher than for Der f1, and samples taken from the dog's coat were more frequently below the level of detection than samples from the living room floor or bedding. Almost all samples contained detectable levels of endotoxin and (1→3)-b-D-glucan. The endotoxin exposure level in the coats …