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Coadministration of mycobacterial protein vaccines and Mycobacterium bovis BCG vaccine

D. N. Wedlock, F. E. Aldwell, H. M. Vordermeier, R. G. Hewinson, B. M. Buddle

VACCINATION with Mycobacterium bovis bacille Calmette-Guérin (BCG) has been shown to induce protection against bovine tuberculosis (TB). This study investigated whether a low dose of oral BCG in combination with a protein vaccine could induce protective immunity to TB while not sensitising cattle to tuberculin.

Eighty Friesian cross female calves were assigned to one of eight groups of 10 animals. One group of calves was vaccinated orally with 2 × 107 colony forming units (cfu) BCG. Two groups were vaccinated with a combination of 2 × 107 cfu oral BCG and one of two protein vaccines containing M bovis culture filtrate proteins (CFPs), while two groups were vaccinated with each of the CFP vaccines alone. One CFP vaccine was formulated with the adjuvants Chitin and Gel01 (administered intranasally), and the second was formulated with Emulsigen and the TLR2 agonist Pam3CSK4 (administered subcutaneously). Two positive control groups were vaccinated orally with 108 cfu BCG or subcutaneously with 106 cfu BCG, while a negative control group remained unvaccinated. All animals were challenged …

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