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Excess vitamin A intake during pregnancy as a possible cause of congenital cleft palate in puppies and kittens
  1. Mike Davies
  1. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD

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I AM currently investigating the role of excess vitamin A intake during the first trimester of pregnancy in causing congenital cleft palate in puppies and kittens, and would like to invite colleagues to send me details about any cases they may see in practice.

In rodents, high vitamin A intake is associated with the development of cleft palate (Nanda 1970), and in rats retinoic acid has been shown to be most potent at causing this effect (Lorente and Miller 1978). In mice, the role of vitamin A intake in enhancing corticosteroid-induced cleft palate has been linked to specific genes (Tyan and Tyan 1993 …

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