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Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia
  1. S. P. Knowler, BSc1,
  2. A. K. McFadyen, PhD, MSc, BSc, DipSAD, Cmath, MIMA, FSS2 and
  3. C. Rusbridge, BVMS, PhD, DipECVN, MRCVS1
  1. Stone Lion Veterinary Hospital, 41 High Street, Wimbledon, SW19 5AU, UK
  2. Reader in Health Statistics, School of Engineering & Computing, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, UK
  1. E-mail for correspondence neuro.vet{at}btinternet.com

Several toy breed dogs are predisposed to syringomyelia (SM), a spinal cord disorder, characterised by fluid-filled cavitation. SM is a complex trait with a moderately high heritability. Selective breeding against SM is confounded by its complex inheritance, its late onset nature and high prevalence in some breeds. This study investigated the early outcome of existing SM breeding guidelines. Six hundred and forty-three dogs, 550 Cavalier King Charles spaniels (CKCS) and 93 Griffon Bruxellois (GB), were identified as having either one (454 dogs) or both parents (189 dogs) with MRI-determined SM status. Offspring without SM were more common when the parents were both clear of SM (SM-free; CKCS 70 per cent, GB 73 per cent). Conversely, offspring with SM were more likely when both parents had SM (SM-affected; CKCS 92 per cent, GB 100 per cent). A mating of one SM-free parent with an SM-affected parent was risky for SM affectedness with 77 per cent of CKCS and 46 per cent of GB offspring being SM-affected. It is recommended that all breeding dogs from breeds susceptible to SM be MRI screened; that the SM status at five years old is established; and all results submitted to a central database that can be used by dog breeders to better enable mate selection based on estimated breeding values.

  • Accepted September 9, 2011.

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  • Accepted September 9, 2011.
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Footnotes

  • Provenance not commissioned; externally peer reviewed

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