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Investigating the association between bovine neonatal pancytopenia and vaccination against BVD

M. Bastian, M. Holsteg, H. Hanke-Robinson, K. Duchow, K. Cussler

ALLOREACTIVE maternal antibodies derived from colostrum have been postulated as the cause of bovine neonatal pancytopenia (BNP). An association between BNP and vaccination against bovine viral diarrhoea (BVD) with PregSure BVD (Pfizer) has also been suggested. This study investigated the role of this vaccine in disease pathogenesis.

Serum samples were obtained from four groups of cattle: BNP dams (which had given birth to a BNP calf) immunised with PregSure BVD; non-BNP dams immunised with PregSure BVD; dams immunised with another BVD vaccine; and dams that had not been vaccinated against BVD. Serum samples from each group were tested by serum neutralisation, flow cytometry and Western blotting. Alloreactive BNP sera were tested to determine whether Fc receptor-mediated phagocytosis was involved in disease pathogenesis. To directly determine whether vaccination against BVD induced alloreactivity, blood samples were tested from guinea pigs immunised with one of four commercial BVD vaccines, and two calves vaccinated four times with a single dose of PregSure BVD. Affinity purification was used to …

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