Veterinary Record 168:241 doi:10.1136/vr.c6776
  • Research
  • Paper

Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial

Open Access
  1. S. Yoon, PhD5
  1. Merial, Centre de Recherche de Saint Vulbas, Parc Industriel de la Plaine de l'Aine, Allee des Cypres, 01150 Saint Vulbas, France
  2. Ambulatorio Veterinario, Via Ennio 25, 20137 Milano, Italy
  3. Clinique Vétérinaire des Roches, 164 rue Jean Baptiste Corot, 38150 Morestel, France
  4. Merial, Kathrinenhof Research Centre, Walchenseestrasse 8-12, 83101 Rohrdorf, Germany
  5. Merial, 3239 Satellite Boulevard, Duluth, GA 30096, USA
  1. E-mail for correspondence derek.baggott{at}

On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcutaneous injection and half received an injection of a saline placebo as the control. All animals were observed daily for 14 days for signs of BRD as defined by set criteria. The proportion of metaphylactic preventive treatment successes, defined as animals surviving to day 14 without signs of BRD, in the gamithromycin-treated group (86 per cent) was significantly (P=0.0012) higher than in the saline-treated controls (61 per cent). Morbidity among the treated animals was reduced by 64 per cent compared with the controls.


  • Provenance not commissioned; externally peer reviewed

This paper is freely available online under the BMJ Journals unlocked scheme, see

Open Access

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