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Effects of short-term oral administration of trimethoprim-sulfamethoxazole on Schirmer II tear test results in clinically normal rabbits
  1. D. Shirani, DVM, PhD1,
  2. M. Selk Ghaffari, DVM, PhD2,
  3. H. Akbarein, DVM, PhD1 and
  4. A. Haji Ali Asgari, DVM1
  1. 1Department of Clinical Sciences, School of Veterinary Medicine, University of Tehran, Tehran, Iran
  2. 2Department of Clinical Sciences, School of Veterinary Medicine, Islamic Azad University – Karaj Branch, Karaj, Iran
  1. Correspondence to Dr Selk Ghaffari, E-mail for correspondence: selkghaffari{at}


Fifteen New Zealand white rabbits were used in a study to determine whether oral administration of trimethoprim-sulfamethoxazole affects the rate of tear secretion in healthy rabbits. Ten rabbits received 40 mg/kg trimethoprim-sulfamethoxazole orally twice a day for 14 days; the other five rabbits were used as a control group and received a placebo during the study. The Schirmer II tear test (STT-II) was performed in both groups during administration of the drugs or placebo on the first, third, seventh and 14th days. Significant decreases in STT-II values were observed in the treatment group on the 14th day of the study in comparison with baseline values (P<0.001).

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