Pharmacokinetics and efficacy of teicoplanin against intramammary infections in sheep
- C. Naccari, DPharm, PhD1,
- P. P. Niutta, DVM, PhD2,
- D. Trombetta, DPharm, PhD1,
- A. De Domenico, DVM, PhD2,
- F. Pizzimenti, DPharm, PhD1,
- P. Cagnardi, DVM, PhD3,
- S. Carli, DVM3 and
- F. Naccari, DBS2
- 1 Department of Pharmacobiology
- 2 Department of Veterinary Public Health, Polo Universitario SS Annunziata, University of Messina, Italy
- 3 Department of Veterinary Sciences and Technologies for Food Safety, University of Milan, Via Celoria 10, Milan, Italy
The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 [0.24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9.23 [0.74] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactiae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.
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