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Glucagon stimulation test for estimating endogenous insulin secretion in dogs
  1. T. Fall, DVM1,
  2. B. Holm, DVM2,
  3. Å. Karlsson, BSc1,
  4. K. M. Ahlgren, MSc3,
  5. O. Kämpe, MD, PhD3 and
  6. H. von Euler, DVM, PhD1
  1. 1 Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), SE-750 07 Uppsala, Sweden
  2. 2 Regiondjursjukhuset Blå Stjärnan, Gjutjärnsg 4, SE-417 07 Göteborg, Sweden
  3. 3 Department of Medical Sciences, University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden

Abstract

Fifty-one dogs (27 diabetic dogs, four that had recovered from diabetes and 20 healthy control dogs) were given 0·5 or 1·0 mg glucagon intravenously. Blood samples were taken before the injection and 10 and 20 minutes after it. Samples were analysed to determine C-peptide, insulin and glucose concentrations, and one sample from each dog was analysed for fructosamine. The median (interquartile range) concentrations of C-peptide in the samples taken at 10 minutes were 0·5 (0·3 to 0·8) nmol/l in the control dogs, 0·1 (0 to 0·2) nmol/l in the diabetic dogs, and 0·3 (0·2 to 0·4) nmol/l in the dogs that had recovered from diabetes. Seven of the 51 dogs showed mild adverse reactions after the injection of glucagon.

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