This article has a correction

Please see: Veterinary Record 2008;163:636

Veterinary Record 163:506-509 doi:10.1136/vr.163.17.506

Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis

  1. K. Mustonen, DVM2
  1. 1 Bio Logic, Savigne sur Lathan, 37340, France
  2. 2 Vetcare, PO Box 26, SF 04601 Mantsala, Finland
  1. Dr and Mrs Banting's present address is La Bergerie, 37230 St Etienne de Chigny, France


One hind quarter of 27 healthy lactating cows was infused with 100 μg Escherichia coli endotoxin. Two hours later, nine of the cows were given physiological saline by intramuscular injection, nine were given 4 mg/kg ketoprofen orally, and nine were given 3 mg/kg ketoprofen by intramuscular injection. Ketoprofen administered either orally or parenterally significantly reduced the effect of the endotoxin on rectal temperature, ruminal contractions and respiratory rate. The size of the udder, the signs of pain and the concentrations of thromboxane B2′, especially in plasma, were also reduced, and the appearance of their milk was almost normal. The response of cows to the oral treatment was as rapid as it was to intramuscular treatment.

    Sign up for job alerts

    Vet Record Careers features a comprehensive database of vet jobs.
    Browse for your next job, or set personalised job alerts so you hear about vacancies as soon as they go online.
    Find out more at Vet Record Careers

    Free Sample Issue

    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of the Veterinary Record.
    View free sample issue >>

    Navigate This Article