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E-cadherin expression in canine cutaneous histiocytomas
  1. S. J. Baines, MA, VetMB, PhD, CertVR, CertSAS, DipECVS, MRCVS1,
  2. E. F. McInnes, BVSc, MRCPath, PhD, MRCVS1 and
  3. I. McConnell, BVM&S, MA, PhD, FRCPath, FRSE, MRCVS1
  1. 1 Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES
  1. Dr Baines' present address is Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA


Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.

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