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Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam
  1. G. M. Friton, DrMedVet1,
  2. H. Schmidt, DrMedVet2 and
  3. W. Schrödl, DrMedVet3
  1. 1 Boehringer Ingelheim Animal Health, Binger Strasse 173, D-55216 Ingelheim am Rhein, Germany
  2. 2 Harlan Bioservice for Science, Sudkampen 31, D-29664 Walsrode, Germany
  3. 3 Institute for Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany

Abstract

The clinical and anti-inflammatory effects of a single treatment of 0·4 mg meloxicam/kg bodyweight on pigs that had been challenged with Escherichia coli endotoxin were investigated. Significantly lower total clinical scores were recorded in pigs treated with meloxicam than in pigs treated with a placebo. Significantly higher mean serum concentrations of thromboxane B2 were also recorded in pigs treated with a placebo for up to 24 hours after the challenge. The serum concentrations of acute phase proteins and specific antibody titres to E coli lipopolysaccharide were unaffected by the meloxicam. The meloxicam treatment was well tolerated.

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