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Anatomical, histological and genetic investigations of a sexually anomalous goat
  1. S. A. Hafez, BVSc1,
  2. W. R. Huckle, PhD1 and
  3. T. Caceci, PhD1
  1. 1Department of Biomedical Sciences and Pathobiology, Virginia- Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Duckpond Drive, Blacksburg, Virginia 24061, USA

Abstract

An apparently female goat was masculine in appearance and had strong male-pattern libido and behaviour. The goat’s DNA was subjected to PCR analysis and its reproductive system was examined anatomically and histologically. The external genitalia consisted of an apparent vulva in the normal position and a grossly enlarged clitoris. Two masses could be palpated lying subcutaneously in the inguinal region; when they were removed they had the macroscopic appearance of hypoplastic testes, and histologically they had atrophic tubules and prominent interstitial tissues. To exclude sex chimaerism, X and Y chromosome-specific targets were amplified by PCR, using bone marrow and muscle DNA templates. The goat had some Y chromosomespecific sequences such as SRY and BRY.I but lacked others, such as BOV97M.

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      Footnotes

      • Dr Hafez is also at the College of Veterinary Medicine, Alexandria University, Egypt

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