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Acute monocytic leukaemia in a cat
  1. N. Nagashima, DVM1,
  2. R. Kano, DVM, PhD1,
  3. A. Hirai, DVM1,
  4. J. Yamazaki1,
  5. C. Inoue1,
  6. M. Hisasue, DVM, PhD2,
  7. P. F. Moore, DVM, PhD3 and
  8. A. Hasegawa, DVM, PhD1
  1. 1Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa Kanagawa, 252-8510, Japan
  2. 2Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Sagamihara City, Kanagawa, 228-8501, Japan
  3. 3Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, 1111 Franklin Street, Oakland, One Shields Avenue, Davis, CA 95616-8739, USA Correspondence to Dr Kano

Abstract

A three-year-old cat with lymphadenopathy, non-regenerative anaemia and marked leucocytosis (171·3 x 109 white blood cells/l) was diagnosed with monocytic leukaemia and treated with a combination of anticancer drugs. A number of mature and immature monocyte-like cells were detected in the peripheral blood and bone marrow; they proved to be monocytic cells by cytochemical examination and an analysis of their cell surface phenotype, indicating that the cat suffered from acute myeloid leukaemia, subclassified as monocytic leukaemia (M5). Treatment with cytarabine, doxorubicin, vincristine and prednisolone greatly reduced the number of blast cells in the cat’s peripheral blood and bone marrow. The cat was in partial remission for 67 days and survived for 95 days after it was first examined.

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